PPARγ differentially regulates energy substrate handling in brown versus white adipose: Focus on “The PPARγ agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake”
نویسندگان
چکیده
To whom correspondence should be addressed: Michael J. Ryan, Ph.D. Assistant Professor University of Mississippi Medical Center Department of Physiology & Biophysics 2500 North State St. Jackson, MS 39216-4505 Office: 601/984-1842 Lab: 601/815-4856 Fax: 601/984-1817 [email protected] Articles in PresS. Am J Physiol Regul Integr Comp Physiol (March 4, 2009). doi:10.1152/ajpregu.00123.2009
منابع مشابه
In Vivo Multi-Tissue Efficacy of Peroxisome Proliferator-Activated Receptor-γ Therapy on Glucose and Fatty Acid Metabolism in Obese Type 2 Diabetic Rats
OBJECTIVE To identify the disturbances in glucose and lipid metabolism observed in type 2 diabetes mellitus, we examined the interaction and contribution of multiple tissues (liver, heart, muscle, and brown adipose tissue) and monitored the effects of the Peroxisome Proliferator-Activated Receptor-γ (PPARγ) agonist rosiglitazone (RGZ) on metabolism in these tissues. DESIGN AND METHODS Rates o...
متن کاملEditorial Focus: PPAR differentially regulates energy substrate handling in brown vs. white adipose: focus on “The PPAR agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake”
PEROXISOME PROLIFERATOR-ACTIVATED receptor (PPAR ) is a nuclear receptor and ligand-activated transcription factor that is highly expressed in brown adipose tissue (BAT) and is necessary for its development (1, 6, 7). BAT is well recognized for its functions in metabolic rate control in rodents (2), and recent work has also identified significant amounts of BAT in adult humans (9). BAT exhibits...
متن کاملThe PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake.
We investigated the mechanisms whereby peroxisome proliferator-activated receptor-gamma (PPARgamma) agonism affects glucose and lipid metabolism in brown adipose tissue (BAT) by studying the impact of PPARgamma activation on BAT glucose uptake and metabolism, lipogenesis, and mRNA levels plus activities of enzymes involved in triacylglycerol (TAG) synthesis. Interscapular BAT of rats treated or...
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Brown adipose tissue (BAT) non-shivering thermogenesis impacts energy homeostasis in rodents and humans. Mitochondrial uncoupling protein 1 in brown fat cells produces heat by dissipating the energy generated by fatty acid and glucose oxidation. In addition to thermogenesis and despite its small relative size, sympathetically activated BAT constitutes an important glucose, fatty acid, and triac...
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Evidence points to a role of the mammalian target of rapamycin (mTOR) signaling pathway as a regulator of adiposity, yet its involvement as a mediator of the positive actions of peroxisome proliferator-activated receptor (PPAR)γ agonism on lipemia, fat accretion, lipid uptake, and its major determinant lipoprotein lipase (LPL) remains to be elucidated. Herein we evaluated the plasma lipid profi...
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